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[857] HYSTERECTOMY AND SEXUAL
DYSFUNCTION: EFFECTS OF SILDENAFIL
IN A CLINICAL SETTING

Laura A. Berman, Jennifer R. Berman, Rahul Padwa, Irwin Goldstein. Boston, MA.

INTRODUCTION -- While the impact of menopause on sexual function is relatively well documented,the sexual impact of surgical menopause through hysterectomy/oopherectomy is still a subject of significant controversy. The goal of this pilot clinical study was 2-fold: 1)to determine the relationship between hysterectomy and sexual complaints and 2)to determine the impact of Sildenafil on resolving those sexual complaints.

METHODS -- 24 women (mean age n=50), 22 with history of hysterectomy, 2 with history of hysterectomy/oopherectomy (average time post-op n=2 years). Oopherectomized patients were on HRT. Patients filled out the Brief Index of Sexual Function for Women (BISF-Q) at baseline and after taking Sildenafil for 6 weeks. Frequency distributions were calculated on descriptive variables and trends were calculated in the form of percentages for complaints with and without Sildenafil. Results were compared using a one-tailed t-test.

RESULTS --

Complaints
(Baseline)
Follow-up
(no sildenafil)
Follow-up
(with Sildenafil)
Low Sensation 100% 22%
Inability to Reach Orgasm 100% 18%
Little/No Sexual Desire 52% 45%
Little/No Lubrication 67% 40%
Pain or Discomfort 68% 33%

CONCLUSIONS -- Further research with larger populations is needed. However, the trends reported here indicate that sensation, inability to reach orgasm, lubrication and pain difficulties are high in this population. Further, post-Sildenafil hysterectomy patients reported a statistically significant decrease in symptoms of low sensation, difficulty reaching orgasm and pain with sexual stimulation or intercourse. Implications of findings for the diagnosis and treatment of FSD as it relates to hysterectomy will be discussed.

 

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