BotanicLab, maker of PC-SPES,
Issues Product Recall

February 8, 2002 --- Following an investigation by the California Department of Health Services (DHS), the company manufacturing PC-SPES has issued a recall of all product. In a letter from John Chen, CEO of BotanicLab (Brea,CA), posted on the company website, DHS analyses of PC-SPES revealed the presence of Warfarin, a synthetic anticoagulant. Pending further investigation, BotanicLab issued the product recall.

Bleeding in patients on PC-SPES has been reported in two isolated cases reported in the medical literature:

1. Weinrobe MC and Montgomery B: Acquired bleeding diathesis in a patient taking PC-SPES.
   N Engl J Med 345: 1213-4, 2001.
2. Lock M, Loblaw DA, Choo R, and Imrie K: Disseminated intravascular coagulation and PC-SPES: a case report and literature review. Can J Urol 8: 1326-9, 2001.

PC SPES and SPES are respectively marketed "for prostate health" and strengthening the immune system. "Consumers should stop using these products and immediately seek medical advice...." California Health Director Diana M. Bontá, R.N., Dr. P.H., said today.

• A press release from the California DHS has been posted on their website.